Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear
Identifieur interne : 002574 ( Main/Exploration ); précédent : 002573; suivant : 002575Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear
Auteurs : T. Sierpinska [Pologne] ; J. Konstantynowicz [Pologne] ; K. Orywal [Pologne] ; M. Golebiewska [Pologne] ; M. Szmitkowski [Pologne]Source :
- Osteoporosis International [ 0937-941X ] ; 2013.
Abstract
The study evaluated if men and women with severe tooth wear were at increased risk of general bone loss. Enamel biopsies obtained from 50 subjects aged 47.5 ± 5 years showed decreased copper content, which was associated with reduced spine bone mineral density, suggesting deficits of this trace element contributing to bone demineralization, enamel attrition, and deteriorated quality of mineralized tissues.
The objective of this cross-sectional study was to assess associations between enamel trace minerals and bone mineral density (BMD) in severe tooth wear. We hypothesized that similar factors contributed to both the excessive abrasion of dental enamel and reduced BMD in subjects with tooth wear.
Fifty patients aged 47.5 ± 5 years with severe tooth wear and 20 age-, sex-, and body mass index (BMI)-matched healthy volunteers with normal dental status were studied regarding dietary intakes of trace elements, serum and salivary copper (Cu), zinc (Zn), and calcium (Ca) concentrations, and serum PTH, osteocalcin, and hydroxyvitamin D levels. Tooth wear was determined using clinical examination based on standard protocol according to Smith and Knight. In all subjects, acid biopsies of the maxillary central incisors were carried out to assess mineral composition of the enamel. Atomic absorption spectroscopy with an air/acetylene flame was used to measure Ca and Zn, and graphite furnace atomic absorption spectroscopy was used to analyze Cu content. BMD was examined using dual energy X-ray absorptiometry.
Tooth wear patients had reduced lumbar spine, but not femoral, BMD relative to controls (
Severe tooth wear is associated with reduced spinal BMD. Enamel in adult individuals with severe tooth wear is low in copper content. Therefore, further work is needed to determine whether copper plays a role in bone pathophysiology in these patients.
Url:
DOI: 10.1007/s00198-013-2410-x
PubMed: 23797848
PubMed Central: 3906556
Affiliations:
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Konstantynowicz</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Pediatrics and Developmental Disorders, Medical University of Bialystok Children’s Teaching Hospital, Waszyngtona Street 17, 15-274 Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatrics and Developmental Disorders, Medical University of Bialystok Children’s Teaching Hospital, Waszyngtona Street 17, 15-274 Bialystok</wicri:regionArea><wicri:noRegion>15-274 Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Orywal, K" sort="Orywal, K" uniqKey="Orywal K" first="K." last="Orywal">K. Orywal</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Golebiewska, M" sort="Golebiewska, M" uniqKey="Golebiewska M" first="M." last="Golebiewska">M. Golebiewska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Szmitkowski, M" sort="Szmitkowski, M" uniqKey="Szmitkowski M" first="M." last="Szmitkowski">M. Szmitkowski</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23797848</idno><idno type="pmc">3906556</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906556</idno><idno type="RBID">PMC:3906556</idno><idno type="doi">10.1007/s00198-013-2410-x</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000D46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D46</idno><idno type="wicri:Area/Pmc/Curation">000D46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D46</idno><idno type="wicri:Area/Pmc/Checkpoint">001A78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A78</idno><idno type="wicri:Area/Ncbi/Merge">004766</idno><idno type="wicri:Area/Ncbi/Curation">004766</idno><idno type="wicri:Area/Ncbi/Checkpoint">004766</idno><idno type="wicri:doubleKey">0937-941X:2013:Sierpinska T:copper:deficit:as</idno><idno type="wicri:Area/Main/Merge">002585</idno><idno type="wicri:Area/Main/Curation">002574</idno><idno type="wicri:Area/Main/Exploration">002574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear</title><author><name sortKey="Sierpinska, T" sort="Sierpinska, T" uniqKey="Sierpinska T" first="T." last="Sierpinska">T. Sierpinska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Konstantynowicz, J" sort="Konstantynowicz, J" uniqKey="Konstantynowicz J" first="J." last="Konstantynowicz">J. Konstantynowicz</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Pediatrics and Developmental Disorders, Medical University of Bialystok Children’s Teaching Hospital, Waszyngtona Street 17, 15-274 Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatrics and Developmental Disorders, Medical University of Bialystok Children’s Teaching Hospital, Waszyngtona Street 17, 15-274 Bialystok</wicri:regionArea><wicri:noRegion>15-274 Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Orywal, K" sort="Orywal, K" uniqKey="Orywal K" first="K." last="Orywal">K. Orywal</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Golebiewska, M" sort="Golebiewska, M" uniqKey="Golebiewska M" first="M." last="Golebiewska">M. Golebiewska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Szmitkowski, M" sort="Szmitkowski, M" uniqKey="Szmitkowski M" first="M." last="Szmitkowski">M. Szmitkowski</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author></analytic><series><title level="j">Osteoporosis International</title><idno type="ISSN">0937-941X</idno><idno type="eISSN">1433-2965</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Summary</title><p>The study evaluated if men and women with severe tooth wear were at increased risk of general bone loss. Enamel biopsies obtained from 50 subjects aged 47.5 ± 5 years showed decreased copper content, which was associated with reduced spine bone mineral density, suggesting deficits of this trace element contributing to bone demineralization, enamel attrition, and deteriorated quality of mineralized tissues.</p></sec><sec><title>Introduction</title><p>The objective of this cross-sectional study was to assess associations between enamel trace minerals and bone mineral density (BMD) in severe tooth wear. We hypothesized that similar factors contributed to both the excessive abrasion of dental enamel and reduced BMD in subjects with tooth wear.</p></sec><sec><title>Methods</title><p>Fifty patients aged 47.5 ± 5 years with severe tooth wear and 20 age-, sex-, and body mass index (BMI)-matched healthy volunteers with normal dental status were studied regarding dietary intakes of trace elements, serum and salivary copper (Cu), zinc (Zn), and calcium (Ca) concentrations, and serum PTH, osteocalcin, and hydroxyvitamin D levels. Tooth wear was determined using clinical examination based on standard protocol according to Smith and Knight. In all subjects, acid biopsies of the maxillary central incisors were carried out to assess mineral composition of the enamel. Atomic absorption spectroscopy with an air/acetylene flame was used to measure Ca and Zn, and graphite furnace atomic absorption spectroscopy was used to analyze Cu content. BMD was examined using dual energy X-ray absorptiometry.</p></sec><sec><title>Results</title><p>Tooth wear patients had reduced lumbar spine, but not femoral, BMD relative to controls (<italic>p</italic> < 0.001). No differences were found in enamel Ca concentration and Zn content was slightly higher in tooth wear patients than in controls whereas Cu content was significantly decreased in the patients: 19.59 ± 16.4 vs 36.86 ± 26.1 μg/l (<italic>p</italic> = 0.01) despite similar levels of Cu in serum and saliva. The differences were independent of serum 25-OH-D, osteocalcin concentrations or PTH either.</p></sec><sec><title>Conclusion</title><p>Severe tooth wear is associated with reduced spinal BMD. Enamel in adult individuals with severe tooth wear is low in copper content. Therefore, further work is needed to determine whether copper plays a role in bone pathophysiology in these patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dervis, E" uniqKey="Dervis E">E Dervis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Suei, Y" uniqKey="Suei Y">Y Suei</name></author><author><name sortKey="Ohtsuka, M" uniqKey="Ohtsuka M">M Ohtsuka</name></author><author><name sortKey="Otani, K" uniqKey="Otani K">K Otani</name></author><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Hollender, Lg" uniqKey="Hollender L">LG Hollender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, Ar" uniqKey="Becker A">AR Becker</name></author><author><name sortKey="Handick, Ke" uniqKey="Handick K">KE Handick</name></author><author><name sortKey="Roberts, We" uniqKey="Roberts W">WE Roberts</name></author><author><name sortKey="Garetto, Lp" uniqKey="Garetto L">LP Garetto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattson, Js" uniqKey="Mattson J">JS Mattson</name></author><author><name sortKey="Cerutis, Dr" uniqKey="Cerutis D">DR Cerutis</name></author><author><name sortKey="Parrish, Lc" uniqKey="Parrish L">LC Parrish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshihara, A" uniqKey="Yoshihara A">A Yoshihara</name></author><author><name sortKey="Seida, Y" uniqKey="Seida Y">Y Seida</name></author><author><name sortKey="Hanada, N" uniqKey="Hanada N">N Hanada</name></author><author><name sortKey="Nakashima, K" uniqKey="Nakashima K">K Nakashima</name></author><author><name sortKey="Miyazaki, H" uniqKey="Miyazaki H">H Miyazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tozum, Tf" uniqKey="Tozum T">TF Tozum</name></author><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammad, Ar" uniqKey="Mohammad A">AR Mohammad</name></author><author><name sortKey="Hooper, Da" uniqKey="Hooper D">DA Hooper</name></author><author><name sortKey="Vermilyea, Sg" uniqKey="Vermilyea S">SG Vermilyea</name></author><author><name sortKey="Mariotti, A" uniqKey="Mariotti A">A Mariotti</name></author><author><name sortKey="Preshaw, Pm" uniqKey="Preshaw P">PM Preshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Suei, Y" uniqKey="Suei Y">Y Suei</name></author><author><name sortKey="Ohtsuka, M" uniqKey="Ohtsuka M">M Ohtsuka</name></author><author><name sortKey="Nakamoto, T" uniqKey="Nakamoto T">T Nakamoto</name></author><author><name sortKey="Lee, K" uniqKey="Lee K">K Lee</name></author><author><name sortKey="Sanada, M" uniqKey="Sanada M">M Sanada</name></author><author><name sortKey="Tsuda, M" uniqKey="Tsuda M">M Tsuda</name></author><author><name sortKey="Ohama, K" uniqKey="Ohama K">K Ohama</name></author><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Bollen, Am" uniqKey="Bollen A">AM Bollen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bando, K" uniqKey="Bando K">K Bando</name></author><author><name sortKey="Nitta, H" uniqKey="Nitta H">H Nitta</name></author><author><name sortKey="Matsubara, M" uniqKey="Matsubara M">M Matsubara</name></author><author><name sortKey="Ishikawa, I" uniqKey="Ishikawa I">I Ishikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundstrom, A" uniqKey="Lundstrom A">A Lundstrom</name></author><author><name sortKey="Jendle, J" uniqKey="Jendle J">J Jendle</name></author><author><name sortKey="Stenstrom, B" uniqKey="Stenstrom B">B Stenstrom</name></author><author><name sortKey="Toss, G" uniqKey="Toss G">G Toss</name></author><author><name sortKey="Ravald, N" uniqKey="Ravald N">N Ravald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshihara, A" uniqKey="Yoshihara A">A Yoshihara</name></author><author><name sortKey="Seida, Y" uniqKey="Seida Y">Y Seida</name></author><author><name sortKey="Hanada, N" uniqKey="Hanada N">N Hanada</name></author><author><name sortKey="Miyazaki, H" uniqKey="Miyazaki H">H Miyazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elders, Pj" uniqKey="Elders P">PJ Elders</name></author><author><name sortKey="Habets, Ll" uniqKey="Habets L">LL Habets</name></author><author><name sortKey="Netelenbos, Jc" uniqKey="Netelenbos J">JC Netelenbos</name></author><author><name sortKey="Van Der Linden, Lw" uniqKey="Van Der Linden L">LW van der Linden</name></author><author><name sortKey="Van Der Stelt, Pf" uniqKey="Van Der Stelt P">PF van der Stelt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inagaki, K" uniqKey="Inagaki K">K Inagaki</name></author><author><name sortKey="Kurosu, Y" uniqKey="Kurosu Y">Y Kurosu</name></author><author><name sortKey="Kamiya, T" uniqKey="Kamiya T">T Kamiya</name></author><author><name sortKey="Kondo, F" uniqKey="Kondo F">F Kondo</name></author><author><name sortKey="Yoshinari, N" uniqKey="Yoshinari N">N Yoshinari</name></author><author><name sortKey="Noguchi, T" uniqKey="Noguchi T">T Noguchi</name></author><author><name sortKey="Krall, Ea" uniqKey="Krall E">EA Krall</name></author><author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weyant, Rj" uniqKey="Weyant R">RJ Weyant</name></author><author><name sortKey="Pearlstein, Me" uniqKey="Pearlstein M">ME Pearlstein</name></author><author><name sortKey="Churak, Ap" uniqKey="Churak A">AP Churak</name></author><author><name sortKey="Forrest, K" uniqKey="Forrest K">K Forrest</name></author><author><name sortKey="Famili, P" uniqKey="Famili P">P Famili</name></author><author><name sortKey="Cauley, Ja" uniqKey="Cauley J">JA Cauley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inagaki, K" uniqKey="Inagaki K">K Inagaki</name></author><author><name sortKey="Kurosu, Y" uniqKey="Kurosu Y">Y Kurosu</name></author><author><name sortKey="Yoshinari, N" uniqKey="Yoshinari N">N Yoshinari</name></author><author><name sortKey="Noguchi, T" uniqKey="Noguchi T">T Noguchi</name></author><author><name sortKey="Krall, Ea" uniqKey="Krall E">EA Krall</name></author><author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Famili, P" uniqKey="Famili P">P Famili</name></author><author><name sortKey="Cauley, J" uniqKey="Cauley J">J Cauley</name></author><author><name sortKey="Suzuki, Jb" uniqKey="Suzuki J">JB Suzuki</name></author><author><name sortKey="Weyant, R" uniqKey="Weyant R">R Weyant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krall, Ea" uniqKey="Krall E">EA Krall</name></author><author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name></author><author><name sortKey="Dawson Hughes, B" uniqKey="Dawson Hughes B">B Dawson-Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krall, Ea" uniqKey="Krall E">EA Krall</name></author><author><name sortKey="Dawson Hughes, B" uniqKey="Dawson Hughes B">B Dawson-Hughes</name></author><author><name sortKey="Papas, A" uniqKey="Papas A">A Papas</name></author><author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Fujiwara, S" uniqKey="Fujiwara S">S Fujiwara</name></author><author><name sortKey="Masunari, N" uniqKey="Masunari N">N Masunari</name></author><author><name sortKey="Suzuki, G" uniqKey="Suzuki G">G Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Suei, Y" uniqKey="Suei Y">Y Suei</name></author><author><name sortKey="Wada, T" uniqKey="Wada T">T Wada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nitta, H" uniqKey="Nitta H">H Nitta</name></author><author><name sortKey="Ishikawa, I" uniqKey="Ishikawa I">I Ishikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahl, Bl" uniqKey="Dahl B">BL Dahl</name></author><author><name sortKey="Carlsson, Ge" uniqKey="Carlsson G">GE Carlsson</name></author><author><name sortKey="Ekfeldt, A" uniqKey="Ekfeldt A">A Ekfeldt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartlett, Dw" uniqKey="Bartlett D">DW Bartlett</name></author><author><name sortKey="Shah, P" uniqKey="Shah P">P Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaeggi, T" uniqKey="Jaeggi T">T Jaeggi</name></author><author><name sortKey="Lussi, A" uniqKey="Lussi A">A Lussi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Attin, T" uniqKey="Attin T">T Attin</name></author><author><name sortKey="Buchalla, W" uniqKey="Buchalla W">W Buchalla</name></author><author><name sortKey="Gollner, M" uniqKey="Gollner M">M Gollner</name></author><author><name sortKey="Hellwig, E" uniqKey="Hellwig E">E Hellwig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisenburger, M" uniqKey="Eisenburger M">M Eisenburger</name></author><author><name sortKey="Addy, M" uniqKey="Addy M">M Addy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisenburger, M" uniqKey="Eisenburger M">M Eisenburger</name></author><author><name sortKey="Addy, M" uniqKey="Addy M">M Addy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdullah, Az" uniqKey="Abdullah A">AZ Abdullah</name></author><author><name sortKey="Strafford, Sm" uniqKey="Strafford S">SM Strafford</name></author><author><name sortKey="Brookes, Sj" uniqKey="Brookes S">SJ Brookes</name></author><author><name sortKey="Duggal, Ms" uniqKey="Duggal M">MS Duggal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Churchley, D" uniqKey="Churchley D">D Churchley</name></author><author><name sortKey="Newby, Cs" uniqKey="Newby C">CS Newby</name></author><author><name sortKey="Willson, R" uniqKey="Willson R">R Willson</name></author><author><name sortKey="Haider, A" uniqKey="Haider A">A Haider</name></author><author><name sortKey="Schemehorn, B" uniqKey="Schemehorn B">B Schemehorn</name></author><author><name sortKey="Lynch, Rjm" uniqKey="Lynch R">RJM Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lynch, Rjm" uniqKey="Lynch R">RJM Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsunaga, T" uniqKey="Matsunaga T">T Matsunaga</name></author><author><name sortKey="Ishizaki, H" uniqKey="Ishizaki H">H Ishizaki</name></author><author><name sortKey="Tanabe, S" uniqKey="Tanabe S">S Tanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brookes, Sj" uniqKey="Brookes S">SJ Brookes</name></author><author><name sortKey="Shore, Rc" uniqKey="Shore R">RC Shore</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C Robinson</name></author><author><name sortKey="Wood, Sr" uniqKey="Wood S">SR Wood</name></author><author><name sortKey="Kirham, J" uniqKey="Kirham J">J Kirham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koulourides, T" uniqKey="Koulourides T">T Koulourides</name></author><author><name sortKey="Feagin, F" uniqKey="Feagin F">F Feagin</name></author><author><name sortKey="Pigman, W" uniqKey="Pigman W">W Pigman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abraham, R" uniqKey="Abraham R">R Abraham</name></author><author><name sortKey="Walton, J" uniqKey="Walton J">J Walton</name></author><author><name sortKey="Russell, L" uniqKey="Russell L">L Russell</name></author><author><name sortKey="Wolman, R" uniqKey="Wolman R">R Wolman</name></author><author><name sortKey="Wardley Smith, B" uniqKey="Wardley Smith B">B Wardley-Smith</name></author><author><name sortKey="Green, Jr" uniqKey="Green J">JR Green</name></author><author><name sortKey="Mitchell, A" uniqKey="Mitchell A">A Mitchell</name></author><author><name sortKey="Reeve, J" uniqKey="Reeve J">J Reeve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tucker, Kl" uniqKey="Tucker K">KL Tucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olivares, M" uniqKey="Olivares M">M Olivares</name></author><author><name sortKey="Uauy, R" uniqKey="Uauy R">R Uauy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Odabasi, E" uniqKey="Odabasi E">E Odabasi</name></author><author><name sortKey="Turan, M" uniqKey="Turan M">M Turan</name></author><author><name sortKey="Aydin, A" uniqKey="Aydin A">A Aydin</name></author><author><name sortKey="Akay, C" uniqKey="Akay C">C Akay</name></author><author><name sortKey="Kutlu, M" uniqKey="Kutlu M">M Kutlu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palacios, C" uniqKey="Palacios C">C Palacios</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Branca, F" uniqKey="Branca F">F Branca</name></author><author><name sortKey="Valtue A, S" uniqKey="Valtue A S">S Valtueña</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vallee, Bl" uniqKey="Vallee B">BL Vallee</name></author><author><name sortKey="Falchuk, Kh" uniqKey="Falchuk K">KH Falchuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medeiros, Dm" uniqKey="Medeiros D">DM Medeiros</name></author><author><name sortKey="Ilich, J" uniqKey="Ilich J">J Ilich</name></author><author><name sortKey="Ireton, J" uniqKey="Ireton J">J Ireton</name></author><author><name sortKey="Matkovic, V" uniqKey="Matkovic V">V Matkovic</name></author><author><name sortKey="Shiry, L" uniqKey="Shiry L">L Shiry</name></author><author><name sortKey="Wildman, R" uniqKey="Wildman R">R Wildman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, B" uniqKey="Smith B">B Smith</name></author><author><name sortKey="Knight, J" uniqKey="Knight J">J Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milosevic, A" uniqKey="Milosevic A">A Milosevic</name></author><author><name sortKey="Dawson, Lj" uniqKey="Dawson L">LJ Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Featherstone, Jd" uniqKey="Featherstone J">JD Featherstone</name></author><author><name sortKey="Lussi, A" uniqKey="Lussi A">A Lussi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lussi, A" uniqKey="Lussi A">A Lussi</name></author><author><name sortKey="Jaeggi, T" uniqKey="Jaeggi T">T Jaeggi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammad, Ar" uniqKey="Mohammad A">AR Mohammad</name></author><author><name sortKey="Bauer, Rl" uniqKey="Bauer R">RL Bauer</name></author><author><name sortKey="Yeh, Ck" uniqKey="Yeh C">CK Yeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="May, H" uniqKey="May H">H May</name></author><author><name sortKey="Reader, R" uniqKey="Reader R">R Reader</name></author><author><name sortKey="Murphy, S" uniqKey="Murphy S">S Murphy</name></author><author><name sortKey="Khaw, Kt" uniqKey="Khaw K">KT Khaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gur, A" uniqKey="Gur A">A Gur</name></author><author><name sortKey="Nas, K" uniqKey="Nas K">K Nas</name></author><author><name sortKey="Kayhan, O" uniqKey="Kayhan O">O Kayhan</name></author><author><name sortKey="Atay, Mb" uniqKey="Atay M">MB Atay</name></author><author><name sortKey="Akyuz, G" uniqKey="Akyuz G">G Akyuz</name></author><author><name sortKey="Sindal, D" uniqKey="Sindal D">D Sindal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roughead, Zk" uniqKey="Roughead Z">ZK Roughead</name></author><author><name sortKey="Lukaski, Hc" uniqKey="Lukaski H">HC Lukaski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klevay, Lm" uniqKey="Klevay L">LM Klevay</name></author><author><name sortKey="Wildman, Re" uniqKey="Wildman R">RE Wildman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonas, J" uniqKey="Jonas J">J Jonas</name></author><author><name sortKey="Burns, J" uniqKey="Burns J">J Burns</name></author><author><name sortKey="Abel, Ew" uniqKey="Abel E">EW Abel</name></author><author><name sortKey="Cresswell, Mj" uniqKey="Cresswell M">MJ Cresswell</name></author><author><name sortKey="Strain, Jj" uniqKey="Strain J">JJ Strain</name></author><author><name sortKey="Paterson, Cr" uniqKey="Paterson C">CR Paterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Preedy, Vr" uniqKey="Preedy V">VR Preedy</name></author><author><name sortKey="Baldwin, Dr" uniqKey="Baldwin D">DR Baldwin</name></author><author><name sortKey="Keating, Jw" uniqKey="Keating J">JW Keating</name></author><author><name sortKey="Salisbury, Jr" uniqKey="Salisbury J">JR Salisbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanumakala, S" uniqKey="Kanumakala S">S Kanumakala</name></author><author><name sortKey="Boneh, A" uniqKey="Boneh A">A Boneh</name></author><author><name sortKey="Zacharin, M" uniqKey="Zacharin M">M Zacharin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahnama, M" uniqKey="Rahnama M">M Rahnama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lichtenegger, Hc" uniqKey="Lichtenegger H">HC Lichtenegger</name></author><author><name sortKey="Schoberl, T" uniqKey="Schoberl T">T Schöberl</name></author><author><name sortKey="Bartl, Mh" uniqKey="Bartl M">MH Bartl</name></author><author><name sortKey="Waite, H" uniqKey="Waite H">H Waite</name></author><author><name sortKey="Stucky, Gd" uniqKey="Stucky G">GD Stucky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strause, L" uniqKey="Strause L">L Strause</name></author><author><name sortKey="Saltman, P" uniqKey="Saltman P">P Saltman</name></author><author><name sortKey="Smith, Kt" uniqKey="Smith K">KT Smith</name></author><author><name sortKey="Bracker, M" uniqKey="Bracker M">M Bracker</name></author><author><name sortKey="Andon, Mb" uniqKey="Andon M">MB Andon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saltman, Pd" uniqKey="Saltman P">PD Saltman</name></author><author><name sortKey="Strause, Lg" uniqKey="Strause L">LG Strause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gur, A" uniqKey="Gur A">A Gür</name></author><author><name sortKey="Colpan, L" uniqKey="Colpan L">L Colpan</name></author><author><name sortKey="Nas, K" uniqKey="Nas K">K Nas</name></author><author><name sortKey="Cevik, R" uniqKey="Cevik R">R Cevik</name></author><author><name sortKey="Sarac, J" uniqKey="Sarac J">J Saraç</name></author><author><name sortKey="Erdo An, F" uniqKey="Erdo An F">F Erdoğan</name></author><author><name sortKey="Duz, Mz" uniqKey="Duz M">MZ Düz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mutlu, M" uniqKey="Mutlu M">M Mutlu</name></author><author><name sortKey="Argun, M" uniqKey="Argun M">M Argun</name></author><author><name sortKey="Kilic, E" uniqKey="Kilic E">E Kilic</name></author><author><name sortKey="Saraymen, R" uniqKey="Saraymen R">R Saraymen</name></author><author><name sortKey="Yazar, S" uniqKey="Yazar S">S Yazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lappalainen, R" uniqKey="Lappalainen R">R Lappalainen</name></author><author><name sortKey="Knuuttila, M" uniqKey="Knuuttila M">M Knuuttila</name></author><author><name sortKey="Lammi, S" uniqKey="Lammi S">S Lammi</name></author><author><name sortKey="Alhava, Em" uniqKey="Alhava E">EM Alhava</name></author><author><name sortKey="Olkkonen, H" uniqKey="Olkkonen H">H Olkkonen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Sierpinska, T" sort="Sierpinska, T" uniqKey="Sierpinska T" first="T." last="Sierpinska">T. Sierpinska</name></noRegion><name sortKey="Golebiewska, M" sort="Golebiewska, M" uniqKey="Golebiewska M" first="M." last="Golebiewska">M. Golebiewska</name><name sortKey="Konstantynowicz, J" sort="Konstantynowicz, J" uniqKey="Konstantynowicz J" first="J." last="Konstantynowicz">J. Konstantynowicz</name><name sortKey="Konstantynowicz, J" sort="Konstantynowicz, J" uniqKey="Konstantynowicz J" first="J." last="Konstantynowicz">J. Konstantynowicz</name><name sortKey="Orywal, K" sort="Orywal, K" uniqKey="Orywal K" first="K." last="Orywal">K. Orywal</name><name sortKey="Szmitkowski, M" sort="Szmitkowski, M" uniqKey="Szmitkowski M" first="M." last="Szmitkowski">M. Szmitkowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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